Apremilast-d5
CAT:
804-HY-12085S-03
Size:
10 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Apremilast-d5
- Product Name Alternative: CC-10004-d5
- CAS Number: 1258597-47-5
- UNSPSC Description: Apremilast-d5 is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1].
- Target Antigen: Apoptosis; Phosphodiesterase (PDE); TNF Receptor
- Type: Isotope-Labeled Compounds
- Related Pathways: Apoptosis;Metabolic Enzyme/Protease
- Field of Research: Inflammation/Immunology
- Purity: 98.63
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: CC(NC1=CC=CC(C(N2[C@@H](C3=CC=C(OC)C(OC([2H])([2H])C([2H])([2H])[2H])=C3)CS(=O)(C)=O)=O)=C1C2=O)=O
- Molecular Weight: 465.53
- References & Citations: [1]Perez-Aso M, et al. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015 Sep 15;17:249.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported