Apremilast-d5

CAT: 0804-HY-12085S-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12085S-01Size:1 mg
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Description
Apremilast-d5 is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1].
CAS Number
[1258597-47-5]
Product Name Alternative
CC-10004-d5
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H315, H319
Target
Apoptosis; Phosphodiesterase (PDE) ; TNF Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
99.26
Solubility
DMSO : 44mg/mL (ultrasonic)
Smiles
CC(NC1=CC=CC(C(N2[C@@H](C3=CC=C(OC)C(OC([2H])([2H])C([2H])([2H])[2H])=C3)CS(=O)(C)=O)=O)=C1C2=O)=O
Molecular Formula
C22H19D5N2O7S
Molecular Weight
465.53
Precautions
H302+H312+H332, H315, H319
References & Citations
[1]Perez-Aso M, et al. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015 Sep 15;17:249.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
PDE4; TNFRSF5/CD40

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