Ac9-25 (TFA)

• Description:

  Ac9-25 TFA, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR[1][2].

• UNSPSC:

  12352209

• Target:

  Formyl Peptide Receptor (FPR)

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ac9-25-tfa.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=CC=C(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CNC3=CC=CC=C23)NC([C@@H](NC([C@H](CCC(N)=O)NC(C)=O)=O)C)=O)=O)CC4=CC=CC=C4)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CC(N)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)C(C)C)=O)[C@@H](C)O)=O)CCC(N)=O)=O)C(C)C)=O)C=C1.OC(C(F)(F)F)=O.[x]

• Molecular Formula:

  C99H143N23O33.xC2HF3O2

• Molecular Weight:

  2183.33 (free acid)

• References & Citations:

  [1]Walther A, et al. A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol Cell. 2000;5 (5) :831-840.|[2]Karlsson J, et al. Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J Leukoc Biol. 2005;78 (3) :762-771.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported