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Sphingomyelin Synthase 1 (SMS1)

CAT: 0579-X2312BSize: 50 µgDry Ice: NoHazardous: No
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CAT#:0579-X2312BSize:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Sphingomyelin Synthase is a bidirectional lipid cholinephosphotransferases capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) in addition to performing the inverse reaction. The direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. It directly and specifically recognizes the choline head group on the substrate. It also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. It may not function strictly as a SM synthase and is inhibited by bacterial PC-phospholipase C inhibitor D609. It is localized to Golgi apparatus; Golgi membrane; multi-pass membrane protein. It can be possibly present on the brain, heart, kidney, liver, muscle and stomach.
Synonyms
SMS1, Sphingomyelin synthase 1,Transmembrane Protein 23, Medulla oblongata-derived Protein, Protein Mob
UniProt
Q86VZ5
Species Reactivity
Human
Conjugation
Unconjugated
Type
Blocking Peptide
Applications
WB
Field of Research
Lipid Mediators
Assay Principle
For use with SMS1 polyclonal antibodies (Cat. No. X2065P and X1701P).
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as solution in phosphate buffered saline
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations
1. Huitema K, van den Dikkenberg J, Brouwers JF, Holthuis JC Identification of a family of animal sphingomyelin synthases. EMBO J. 2004 Jan 14;23(1):33-44. Epub 2003 Dec 18.
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB

UniProtKB · Q86VZ5

Phosphatidylcholine:ceramide cholinephosphotransferase 1

SMS1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q86VZ5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SGMS1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.8.27
Processing
—
Secondary accessions
D3DWC4, Q68U43, Q6EKK0, Q75SP1
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisLipid metabolismSphingolipid metabolism

Cellular component

Golgi apparatusMembrane

Molecular function

KinaseTransferase

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix

Related Products

CatalogName
X2065PRabbit anti Human Sphingomyelin Synthase 1
X1861PRabbit anti Drosophila Sphingomyelin synthase-related protein 1
X1704PRabbit anti Human Sphingomyelin synthase-related protein 1
X1701PRabbit anti Human Sphingomyelin Synthase 1 (Peptide as antigen)
X2059PRabbit anti Human Sphingomyelin Synthase 2
X1703PRabbit anti Human Sphingomyelin Synthase 2 (Peptide as antigen)
X2287BSphingomyelin Phosphodiesterase 3
X2360PRabbit anti Human Sphingomyelin Phosphodiesterase 3
X2359PRabbit anti Human Sphingomyelin Phosphodiesterase 3
NE040/7SRabbit anti Porcine Citrate synthase

Alternative Products

CatalogName
MBS396391-01Sphingomyelin Synthase 1 (SMS1)
ELK0033-01Human SMS1 (Sphingomyelin Synthase 1) ELISA Kit
041667SGMS1, NT (SGMS1, MOB, SMS1, TMEM23, Phosphatidylcholine:ceramide cholinephosphotransferase 1, Medulla oblongata-derived protein, Sphingomyelin synthase 1, Transmembrane protein 23)
MBS6347002-01SGMS1, NT (SGMS1, MOB, SMS1, TMEM23, Phosphatidylcholine:ceramide cholinephosphotransferase 1, Medulla oblongata-derived protein, Sphingomyelin synthase 1, Transmembrane protein 23) (FITC)
MBS6347000-01SGMS1, NT (SGMS1, MOB, SMS1, TMEM23, Phosphatidylcholine:ceramide cholinephosphotransferase 1, Medulla oblongata-derived protein, Sphingomyelin synthase 1, Transmembrane protein 23) (APC)
MBS6347009-01SGMS1, NT (SGMS1, MOB, SMS1, TMEM23, Phosphatidylcholine:ceramide cholinephosphotransferase 1, Medulla oblongata-derived protein, Sphingomyelin synthase 1, Transmembrane protein 23) (PE)
MBS6347001-01SGMS1, NT (SGMS1, MOB, SMS1, TMEM23, Phosphatidylcholine:ceramide cholinephosphotransferase 1, Medulla oblongata-derived protein, Sphingomyelin synthase 1, Transmembrane protein 23) (Biotin)
MBS6346999-01SGMS1, NT (SGMS1, MOB, SMS1, TMEM23, Phosphatidylcholine:ceramide cholinephosphotransferase 1, Medulla oblongata-derived protein, Sphingomyelin synthase 1, Transmembrane protein 23) (AP)
041667-FITCSGMS1, NT (SGMS1, MOB, SMS1, TMEM23, Phosphatidylcholine:ceramide cholinephosphotransferase 1, Medulla oblongata-derived protein, Sphingomyelin synthase 1, Transmembrane protein 23) (FITC) discontinued
041667-PESGMS1, NT (SGMS1, MOB, SMS1, TMEM23, Phosphatidylcholine:ceramide cholinephosphotransferase 1, Medulla oblongata-derived protein, Sphingomyelin synthase 1, Transmembrane protein 23) (PE) discontinued

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