Sphingomyelin Phosphodiesterase 3

Sphingomyelin Phosphodiesterase 3

• Background: Sphingomyelin phosphodiesterase 3 catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these two cellular events independently. It also hydrolyzes sphingosylphosphocholine. Sphingomyelin phosphodiesterase 3 regulates the cell cycle by acting as a growth suppressor in confluent cells. It likely acts as a regulator of postnatal development and participates in bone and dentin mineralization. It is activated by unsaturated fatty acids and phosphatidylserine. it is predominantly expressed in the brain.
• Synonyms: nSMase2, Neutral sphingomyelinase 2, EC 3.1.4.12
• UniProt: Q9NY59
• Host: Rabbit
• Species Reactivity: Human
• Conjugation: Unconjugated
• Type: Blocking Peptide
• Applications: WB
• Assay Principle: For use with Sphingomyelin Phosphodiesterase 3 polyclonal antibodies (Cat. No. X2359P , X2360P).
• Stability: See expiration date on vial
• Concentration: See vial for Concentration
• Form: Provided as solution in phosphate buffered saline
• Precautions: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
• Shipping Conditions: Ambient Temperature, freeze upon arrival
• Storage Conditions: Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
• Functional Analysis: WB