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5,7,8-Trimethoxyflavone

CAT: 0804-HY-N7656-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7656-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether), isolated from Andrographis echioides, inhibits NO with an IC50 of 39.1 μM. 5,7,8-Trimethoxyflavone has anti-inflammatory activity[1].
CAS Number
23050-38-6
Product Name Alternative
Norwogonin 5,7,8-trimethyl ether
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
NO Synthase
Type
Natural Products
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/5-7-8-trimethoxyflavone.html
Purity
99.7
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=CC=CC=C2)OC3=C(OC)C(OC)=CC(OC)=C13
Molecular Formula
C18H16O5
Molecular Weight
312.32
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]De-Yang Shen, et al. Chemical constituents from Andrographis echioides and their anti-inflammatory activity. Int J Mol Sci. 2012 Dec 27;14 (1) :496-514.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Chemical Information

Norwogonin 5,7,8-trimethyl ether

5,7,8-trimethoxy-2-phenylchromen-4-one has been reported in Uvaria welwitschii with data available.

CAS Number23050-38-6
PubChem CID14756218
IUPAC Name5,7,8-trimethoxy-2-phenylchromen-4-one
Molecular FormulaC18H16O5
Molecular Weight312.3
XLogP3.1
Topological Polar Surface Area54
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count23
Formal Charge0
Complexity454
SMILES
COC1=CC(=C(C2=C1C(=O)C=C(O2)C3=CC=CC=C3)OC)OC
InChI
InChI=1S/C18H16O5/c1-20-14-10-15(21-2)17(22-3)18-16(14)12(19)9-13(23-18)11-7-5-4-6-8-11/h4-10H,1-3H3
InChIKey
VFRLJCKMHUJGFR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Norwogonin 5,7,8-trimethyl ether
CAS: 23050-38-6
CID: 14756218
Formula: C18H16O5
MW: 312.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight312.3
XLogP33.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass312.09977361
Monoisotopic Mass312.09977361
Topological Polar Surface Area54 Ų
Heavy Atom Count23
Formal Charge0
Complexity454
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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