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Navtemadlin-d7

CAT: 0804-HY-12296S-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12296S-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Navtemadlin-d7 is the deuterium labeled Navtemadlin. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[1][2].
Product Name Alternative
AMG 232-d7; KRT-232-d7
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; Isotope-Labeled Compounds; MDM-2/p53
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C(O)C[C@]1(C)C(N([C@H](CS(=O)(C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)C(C)C)[C@H](C2=CC=C(Cl)C=C2)[C@@H](C3=CC=CC(Cl)=C3)C1)=O
Molecular Formula
C28H28D7Cl2NO5S
Molecular Weight
575.60
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Canon J, et al. The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents. Mol Cancer Ther. 2015 Mar;14 (3) :649-58.|[3]Rew Y, et al. Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer. J Med Chem. 2014 Aug 14;57 (15) :6332-41.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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CatalogName
TQ0127-01Navtemadlin
MBS6047775-01Carbaryl-d7 (1-Naphthalenol Methylcarbamate-d7, 1-Naphtyl N-Methylcarbamate-d7, ENT-23969-d7, OMS-29-d7, UC-7744-d7, Carylderm-d7, Derbac-d7, Ravyon-d7, Sevin-d7)
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C1082Carbaryl-d7 (1-Naphthalenol Methylcarbamate-d7, 1-Naphtyl N-Methylcarbamate-d7, _x000B_ENT-23969-d7, OMS-29-d7, UC-7744-d7, Carylderm-d7, Derbac-d7, Ravyon-d7, Sevin-d7)
RM-P181528-01Propranolol-D7 (Naphthalenyl-D7)
CS-C-01232(+/-) -Ropivacaine-d7 (propyl-d7)
TRC-F598826-100MGFlurprimidol D7 (Isopropyl D7)
CS-T-60821Propranolol-d7 (ring-d7)
CS-O-47499Butylphthalide D7 (NBP D7)

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