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Navtemadlin

CAT: 0931-TQ0127-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-TQ0127-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1352066-68-2
Target
MDM-2/p53, Mdm2, E1/E2/E3 Enzyme
Related Pathways
Ubiquitination, Apoptosis
Purity
0.9908
Bioactivity
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM) . It binds to MDM2 with a Kd of 0.045 nM.
Smiles
CC(C)[C@@H](CS(=O)(=O)C(C)C)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Molecular Formula
C28H35Cl2NO5S
Molecular Weight
568.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-12296-01Navtemadlin
HY-12296S-01Navtemadlin-d7
HY-12296A-01(3S,5S,6R) -Navtemadlin

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