Eperisone (hydrochloride)

CAT: 0804-HY-B1901-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1901-01Size:25 mg
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Description
Eperisone Hydrochloride ((±) -Eperisone hydrochloride) is an orally active antispastic agent with a vasodilator effect, used for the research of muscle stiffness and pain. Eperisone Hydrochloride is a potent and selectively P2X7 receptor antagonist, also shows antagonism for human P2X3. Eperisone Hydrochloride works by relaxing both skeletal muscles and vascularsmooth muscles, demonstrating a variety of effects such as reduction ofmyotonia, improvement of circulationand and suppression of the pain reflex[1][2][3][4][5][6].
CAS Number
[56839-43-1]
Product Name Alternative
(±) -Eperisone (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/eperisone-hydrochloride.html
Purity
99.95
Solubility
DMSO : 31.25 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(CC)C=C1)C(C)CN2CCCCC2.[H]Cl
Molecular Formula
C17H26ClNO
Molecular Weight
295.85
Precautions
H302, H315, H319, H335
References & Citations
[1]Cabitza P, et al. Efficacy and safety of eperisone in patients with low back pain: a double blind randomized study. Eur Rev Med Pharmacol Sci. 2008 Jul-Aug;12 (4) :229-35.|[2]Frandisco Colomer Rusinvol, et al. Effects of Two Diffferent Doses of Eperisone in the Treatment of Acute Low Back Pain. The Journal of Applied Research.|[3]Bavage S, et al. Clinical efficacy and safety of eperisone for low back pain: A systematic literature review. Pharmacol Rep. 2016 Oct;68 (5) :903-12.|[4]Park KH, Lee SC, Yuk JE, Kim SR, Lee JH, Park JW. Eperisone-Induced Anaphylaxis: Pharmacovigilance Data and Results of Allergy Testing. Allergy Asthma Immunol Res. 2019;11 (2) :231-240. |[5]Tanaka KI, et al. Therapeutic effects of eperisone on pulmonary fibrosis via preferential suppression of fibroblast activity. Cell Death Discov. 2022 Feb 8;8 (1) :52.|[6]Okada M, et al. Eperisone Hydrochloride, a Muscle Relaxant, Is a Potent P2X7 Receptor Antagonist. Chem Pharm Bull (Tokyo) . 2024;72 (3) :345-348.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched

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