Products for Research Use Only
RegisterLogin

Clindamycin-13C, d3

CAT: 0804-HY-B1455S1Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B1455S1Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Clindamycin-13C, d3 is the 13C- and deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs) . Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA) . Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla) . Clindamycin also can be used for researching malaria[1][2][3].
CAS Number
2140264-63-5
UNSPSC
12352005
Target
Antibiotic; Bacterial; Isotope-Labeled Compounds; Parasite
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Applications
COVID-19-immunoregulation
Field of Research
Infection
Purity
99.94
Solubility
10 mM in DMSO|DMSO : 125mg/mL (ultrasonic)
Smiles
O=C([C@@H]1C[C@H](CN1[13C]([2H])([2H])[2H])CCC)N[C@@H]([C@@]2([H])O[C@@H]([C@@H]([C@H]([C@H]2O)O)O)SC)[C@@H](Cl)C
Molecular Formula
C17 13CH30D3ClN2O5S
Molecular Weight
428.99
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-223.|[2]Hodille E, et al. Clindamycin suppresses virulence expression in inducible clindamycin-resistant Staphylococcus aureus strains. Ann Clin Microbiol Antimicrob. 2018 Oct 20;17 (1) :38.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Plasmodium

Chemical Information

Clindamycin-13C,d3
CAS Number2140264-63-5
PubChem CID76973454
IUPAC Name(2S,4R)-N-[(1S,2S)-2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-4-propyl-1-(trideuterio(113C)methyl)pyrrolidine-2-carboxamide
Molecular FormulaC18H33ClN2O5S
Molecular Weight429.0
XLogP2.2
Topological Polar Surface Area128
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count27
Formal Charge0
Complexity502
SMILES
[2H][13C]([2H])([2H])N1C[C@@H](C[C@H]1C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@H](C)Cl)CCC
InChI
InChI=1S/C18H33ClN2O5S/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25)/t9-,10+,11-,12+,13-,14+,15+,16+,18+/m0/s1/i3+1D3
InChIKey
KDLRVYVGXIQJDK-ARPHVQDSSA-N
Chemical Structure
2D Structure
2D structure of Clindamycin-13C,d3
CAS: 2140264-63-5
CID: 76973454
Formula: C18H33ClN2O5S
MW: 429.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight429.0
XLogP32.2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass428.2020561
Monoisotopic Mass428.2020561
Topological Polar Surface Area128 Ų
Heavy Atom Count27
Formal Charge0
Complexity502
Isotope Atom Count4
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-W749665-01Clindamycin Hydrochloride-13C, d3
HY-B1455SClindamycin-d3 (hydrochloride)
HY-106827S1Trimegestone-13C, d3
HY-10219S1-01Rapamycin-13C, d3
HY-B0002BS2Ondansetron-13C, d3
HY-15651SAlvelestat-13C, d3
HY-B0251S1Eplerenone-13C, d3
HY-143848STadalafil-13C, d3
HY-15408STrelagliptin-13C, d3
HY-10241S-01Simeprevir-13C, d3

Alternative Products

CatalogName
RM-C120525-01Clindamycin-13C-D3
TRC-C579992-1MGClindamycin-13C,D3
444869-01Clindamycin-13C, D3
TRC-C579994-0.5MGClindamycin-13C,D3 Hydrochloride
CS-O-03671Clindamycin-13C, d3 Hydrochloride
444870-01Clindamycin-13C, D3 Sulfoxide
CS-EQ-00268Clindamycin Sulfoxide-13C D3
AR-C03123-01Clindamycin Sulfoxide-13C-d3
TRC-C580012-2.5MGClindamycin-13C,D3 Sulfoxide
AR-C07948-01Clindamycin-13C-d3-2-Phosphate

Popular Products