Dibenz[a,h]anthracene

• UNSPSC Description:

  Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms[1][2].

• Target Antigen:

  Apoptosis; DNA/RNA Synthesis; MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dibenz-a-h-anthracene.html

• Purity:

  98.0

• Solubility:

  DMSO : 5 mg/mL (ultrasonic)

• Smiles:

  C12=CC=CC=C1C3=CC(C=CC4=CC=CC=C45)=C5C=C3C=C2

• Molecular Weight:

  278.35

• References & Citations:

  [1]K L Platt, et al.  Stereoselective metabolism of dibenz(a,h)anthracene to trans-dihydrodiols and their activation to bacterial mutagens. Environ Health Perspect. 1990 Aug:88:37-41.|[2]Amal I Malik, et al. Hepatic genotoxicity and toxicogenomic responses in Muta™Mouse males treated with dibenz[a,h]anthracene. Mutagenesis. 2013 Sep;28(5):543-54.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Phase 3

• CAS Number:

  53-70-3