Dibenz[a,h]anthracene

Dibenz[a,h]anthracene

• CAS Number: 53-70-3
• UNSPSC Description: Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms[1][2].
• Target Antigen: Apoptosis; DNA/RNA Synthesis; MDM-2/p53
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/dibenz-a-h-anthracene.html
• Purity: 98.0
• Solubility: DMSO : 5 mg/mL (ultrasonic)
• Smiles: C12=CC=CC=C1C3=CC(C=CC4=CC=CC=C45)=C5C=C3C=C2
• Molecular Weight: 278.35
• References & Citations: [1]K L Platt, et al.  Stereoselective metabolism of dibenz(a,h)anthracene to trans-dihydrodiols and their activation to bacterial mutagens. Environ Health Perspect. 1990 Aug:88:37-41.|[2]Amal I Malik, et al. Hepatic genotoxicity and toxicogenomic responses in Muta™Mouse males treated with dibenz[a,h]anthracene. Mutagenesis. 2013 Sep;28(5):543-54.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Phase 3