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Dibenz[a, h]anthracene

CAT: 0804-HY-W013053-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W013053-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dibenz[a, h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a, h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a, h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms[1][2].
CAS Number
53-70-3
Product Name Alternative
DBA; 1,2,5,6-Dibenzanthracene; Benzo[k]tetraphene
UNSPSC
12352005
Hazard Statement
H350, H410
Target
Apoptosis; DNA/RNA Synthesis; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dibenz-a-h-anthracene.html
Purity
98.0
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
C12=CC=CC=C1C3=CC(C=CC4=CC=CC=C45)=C5C=C3C=C2
Molecular Formula
C22H14
Molecular Weight
278.35
Precautions
H350, H410
References & Citations
[1]K L Platt, et al. Stereoselective metabolism of dibenz (a, h) anthracene to trans-dihydrodiols and their activation to bacterial mutagens. Environ Health Perspect. 1990 Aug:88:37-41.|[2]Amal I Malik, et al. Hepatic genotoxicity and toxicogenomic responses in Muta™Mouse males treated with dibenz[a, h]anthracene. Mutagenesis. 2013 Sep;28 (5) :543-54.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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