Maceneolignan H

• Description :

  Maceneolignan H (Compound 8) is a neolignane compound isolated from the arils of Myristica fragrans. Maceneolignan H is a selective CCR3 antagonist (EC50 = 1.4 μM) . Maceneolignan H has the potential for the research of allergic diseases[1].

• UNSPSC :

  12352005

• Target :

  CCR

• Type :

  Natural Products

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/maceneolignan-h.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@H]([C@@H](C(C=C1)=CC(OC)=C1OC)OC(C)=O)OC(C(OC)=CC(CC=C)=C2)=C2OC

• Molecular Formula :

  C24H30O7

• Molecular Weight :

  430.49

• References & Citations :

  [1]Morikawa T, et al. Neolignans from the Arils of Myristica fragrans as Potent Antagonists of CC Chemokine Receptor 3. J Nat Prod. 2016;79 (8) :2005-2013.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  CCR3

• CAS Number :

  [1314042-85-7]