MIND4-19

• Description :

  MIND4-19 is a potent SIRT2 inhibitor with an IC50 value of 7.0 μM. MIND4-19 can be used for researching Huntington's disease[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319

• Target :

  Sirtuin

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/mind4-19.html

• Purity :

  99.93

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  C1(COC2=CC=CC=C2)=NN=C(SCC3=CC=CC=C3)N1C4=CC=CC=C4

• Molecular Formula :

  C22H19N3OS

• Molecular Weight :

  373.47

• Precautions :

  H315, H319

• References & Citations :

  [1]Quinti L, et al. SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models. Cell Chem Biol. 2016 Jul 21;23 (7) :849-861.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  SIRT2

• CAS Number :

  [129544-85-0]