AKT-IN-3

AKT-IN-3

• CAS Number: 2374740-21-1
• UNSPSC Description: AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells[1].
• Target Antigen: Akt; Apoptosis
• Type: Reference compound
• Related Pathways: Apoptosis;PI3K/Akt/mTOR
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/akt-in-3.html
• Purity: 99.29
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: CNC(C[C@H]1NC[C@@H](NC(C2=CC(C3=C(Cl)C=NN3C)=C(Cl)O2)=O)[C@H](C4=CC(F)=C(F)C=C4)C1)=O
• Molecular Weight: 526.36
• References & Citations: [1]Dong X, et al. Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design. J Med Chem. 2019 Aug 8;62(15):7264-7288.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported