GMA-839

CAT: 0804-HY-117955Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-117955Size:1 Each
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Description
GMA-839 is a selective modulator of the γ-aminobutyric acid A receptor (GABAA) with an IC50 value of 230 nM. GMA-839 exhibits potent anxiolytic-like activity, demonstrating significant dose-dependent anxiolytic effects in animal models, with an effective oral dose of 1.6 mg/kg. Significant increases in punished responding were observed in squirrel monkeys and pigeons. GMA-839 shows promise for research in the field of anxiolytics[1].
CAS Number
[162882-76-0]
Product Name Alternative
WAY 141839; Co 2-6749
UNSPSC
12352211
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gma-839.html
Smiles
FC(F)(F)[C@]1(CC[C@@]2([C@]3(CC[C@@]4([C@H](CC[C@]4([C@@]3(CC[C@@]2(C1)[H])[H])[H])C(CO)=O)C)[H])[H])O
Molecular Formula
C21H31F3O3
Molecular Weight
388.46
References & Citations
[1]Vanover KE, et al. Characterization of the anxiolytic properties of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3alpha, 21-dihydroxy-3beta-trifluoromethyl-19-nor-5beta-pregnan-20-one), a selective modulator of gamma-aminobutyric acid (A) receptors. J Pharmacol Exp Ther. 2000 Oct;295 (1) :337-45.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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