(1R)-IDH889

(1R)-IDH889

• CAS Number: 1429179-08-7
• UNSPSC Description: (1R)-IDH889 is the isomer of IDH889 (HY-112289), and can be used as an experimental control. IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM[1].
• Target Antigen: Isocitrate Dehydrogenase (IDH)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/1r-idh889.html
• Purity: 98.83
• Solubility: DMSO : 200 mg/mL (ultrasonic)
• Smiles: O=C1OC[C@H](C(C)C)N1C2=NC(N[C@@H](C3=NC=C(C4=CC=C(F)C(C)=C4)C=N3)C)=NC=C2
• Molecular Weight: 436.48
• References & Citations: [1]Levell JR, et al. Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1. ACS Med Chem Lett. 2016 Dec 16;8(2):151-156.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported