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IDH889

CAT: 0804-HY-112289-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112289-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1) . IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM[1].
CAS Number
1429179-07-6
UNSPSC
12352005
Target
Isocitrate Dehydrogenase (IDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/idh889.html
Purity
99.96
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C1OC[C@H](C(C)C)N1C2=NC(N[C@H](C3=NC=C(C4=CC=C(F)C(C)=C4)C=N3)C)=NC=C2
Molecular Formula
C23H25FN6O2
Molecular Weight
436.48
References & Citations
[1]Levell JR, et al. Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1. ACS Med Chem Lett. 2016 Dec 16;8 (2) :151-156.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDH1

Alternative Products

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BA7853-5IDH889
A19578-50IDH889 50mg
A19578-1IDH889 1mg
A19578-10IDH889 10mg
A19578-100IDH889 100mg
A19578-25IDH889 25mg
A19578-5IDH889 5mg
A19578-10mM-DIDH889 10mM * 1mL in DMSO

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