Sinomenine hydrochloride

Sinomenine hydrochloride

• CAS Number: 6080-33-7
• UNSPSC Description: Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from?Sinomenium acutum, is a blocker of the NF-κB activation[1]. Sinomenine also is an activator of μ-opioid receptor[2].
• Target Antigen: Apoptosis; Autophagy; NF-κB; Opioid Receptor
• Type: Natural Products
• Related Pathways: Apoptosis;Autophagy;GPCR/G Protein;Neuronal Signaling;NF-κB
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/Sinomenine_hydrochloride.html
• Solubility: DMSO : 100 mg/mL (ultrasonic;warming)|H2O : 16.67 mg/mL (ultrasonic)
• Smiles: OC(C1=C2C[C@@]3([H])[C@](C=C4OC)([H])[C@@]1(CCN3C)CC4=O)=C(C=C2)OC.Cl
• Molecular Weight: 365.85
• References & Citations: [1]Song L, et al. Sinomenine inhibits breast cancer cell invasion and migration by suppressing NF-κB activation mediated by IL-4/miR-324-5p/CUEDC2 axis. Biochem Biophys Res Commun. 2015 Aug 28;464(3):705-10.|[2]Gao T, et al. Analgesic effect of sinomenine in rodents after inflammation and nerve injury. Eur J Pharmacol. 2013 Dec 5;721(1-3):5-11.|[3]Zhu Q, et al. Antinociceptive effects of sinomenine in a rat model of neuropathic pain. Sci Rep. 2014 Dec 1;4:7270.|[4]Wang MH, et al. Activation of opioid mu-receptor by sinomenine in cell and mice.Neurosci Lett. 2008 Oct 10;443(3):209-12.bioRxiv. 2023 Jun 3.|Free Radic Biol Med. 2018 Jun 2;124:205-213.|Immun Inflamm Dis. 2024 Jun;12(6):e1271.|Acta Pharm Sin B. 2021 Nov;11(11):3465-3480.|Chem Biol Drug Des. 2022 Oct 27.|Drug Des Devel Ther. 2024 Aug 6:18:3523-3545.|Exp Ther Med. 2021 Apr 18.|Heliyon. 2024 June 23.|J Inflamm Res. 2023 Oct 20:16:4777-4791.|Phytother Res. 2023 Apr 10.|PLoS Biol. 2024 June 27.|World J Stem Cells. 2024 May 26.
• Shipping Conditions: Room Temperature
• Clinical Information: Launched