Sinomenine (Standard)

• Description :

  Sinomenine (Standard) is the analytical standard of Sinomenine. This product is intended for research and analytical applications. Sinomenine, an alkaloid extracted from?Sinomenium acutum, is a blocker of the NF-κB activation[1]. Sinomenine also is an activator of μ-opioid receptor[2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335, H351, H361, H372

• Target :

  Apoptosis; Autophagy; NF-κB; Opioid Receptor; Reference Standards

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling; NF-κB; Others

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/sinomenine-standard.html

• Purity :

  99.99

• Smiles :

  OC(C1=C2C[C@@]3([H])[C@](C=C4OC)([H])[C@@]1(CCN3C)CC4=O)=C(C=C2)OC

• Molecular Formula :

  C19H23NO4

• Molecular Weight :

  329.39

• Precautions :

  H302, H315, H319, H335, H351, H361, H372

• References & Citations :

  [1]Song L, et al. Sinomenine inhibits breast cancer cell invasion and migration by suppressing NF-κB activation mediated by IL-4/miR-324-5p/CUEDC2 axis. Biochem Biophys Res Commun. 2015 Aug 28;464 (3) :705-10.|[2]Gao T, et al. Analgesic effect of sinomenine in rodents after inflammation and nerve injury. Eur J Pharmacol. 2013 Dec 5;721 (1-3) :5-11.|[3]Zhu Q, et al. Antinociceptive effects of sinomenine in a rat model of neuropathic pain. Sci Rep. 2014 Dec 1;4:7270.|[4]Wang MH, et al. Activation of opioid mu-receptor by sinomenine in cell and mice.Neurosci Lett. 2008 Oct 10;443 (3) :209-12.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C, sealed storage, away from light and moisture

• Scientific Category :

  Reference Standards

• CAS Number :

  [115-53-7]