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Sinomenine (Standard)

CAT: 0804-HY-15122R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15122R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sinomenine (Standard) is the analytical standard of Sinomenine. This product is intended for research and analytical applications. Sinomenine, an alkaloid extracted from?Sinomenium acutum, is a blocker of the NF-κB activation[1]. Sinomenine also is an activator of μ-opioid receptor[2].
CAS Number
115-53-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335, H351, H361, H372
Target
Apoptosis; Autophagy; NF-κB; Opioid Receptor; Reference Standards
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling; NF-κB; Others
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sinomenine-standard.html
Purity
99.99
Smiles
OC(C1=C2C[C@@]3([H])[C@](C=C4OC)([H])[C@@]1(CCN3C)CC4=O)=C(C=C2)OC
Molecular Formula
C19H23NO4
Molecular Weight
329.39
Precautions
H302, H315, H319, H335, H351, H361, H372
References & Citations
[1]Song L, et al. Sinomenine inhibits breast cancer cell invasion and migration by suppressing NF-κB activation mediated by IL-4/miR-324-5p/CUEDC2 axis. Biochem Biophys Res Commun. 2015 Aug 28;464 (3) :705-10.|[2]Gao T, et al. Analgesic effect of sinomenine in rodents after inflammation and nerve injury. Eur J Pharmacol. 2013 Dec 5;721 (1-3) :5-11.|[3]Zhu Q, et al. Antinociceptive effects of sinomenine in a rat model of neuropathic pain. Sci Rep. 2014 Dec 1;4:7270.|[4]Wang MH, et al. Activation of opioid mu-receptor by sinomenine in cell and mice.Neurosci Lett. 2008 Oct 10;443 (3) :209-12.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards

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