PTK7/β-catenin-IN-1

PTK7/β-catenin-IN-1

• CAS Number: 906147-24-8
• UNSPSC Description: PTK7/β-catenin-IN-1 (compound 01065) is a potent PTK7/β-catenin inhibitor with an IC50 of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 has the potential for cancer research[1].
• Target Antigen: β-catenin
• Type: Reference compound
• Related Pathways: Stem Cell/Wnt
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ptk7-β-catenin-in-1.html
• Solubility: DMSO : 60 mg/mL (ultrasonic)
• Smiles: O=C(C(C1=CNC2=C1C=CC=C2)=O)NC3=C(C4=CC=CC=C4)C=CC=C3
• Molecular Weight: 340.37
• References & Citations: [1]Laetitia Ganier, et al. Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer. ACS Chem Biol. 2022 May 20;17(5):1061-1072.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported