PTK7/β-catenin-IN-2

PTK7/β-catenin-IN-2

• CAS Number: 902434-29-1
• UNSPSC Description: PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of PTK7/β-catenin. It inhibits the binding of PTK7 to β-catenin (IC50: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC50 of 157.1 μM[1].
• Target Antigen: β-catenin
• Type: Reference compound
• Related Pathways: Stem Cell/Wnt
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/ptk7-β-catenin-in-2.html
• Solubility: DMF : 25 mg/mL (ultrasonic)
• Smiles: O=C(CCC1=C(C)N2N=C(C3=CC=C(Cl)C=C3)C=C2N=C1C)NCCCN4CCN(CC4)C5=CC(Cl)=CC=C5
• Molecular Weight: 565.54
• References & Citations: [1]Ganier L, et al. Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer[J]. ACS Chemical Biology, 2022, 17(5): 1061-1072.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported