[D-Trp8]-γ-MSH

[D-Trp8]-γ-MSH

• CAS Number: 321351-81-9
• UNSPSC Description: [D-Trp8]-γ-MSH is a potent and selective agonist of melanocortin 3 (MC3) receptor, with IC50s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4 and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis[1][2].
• Target Antigen: Melanocortin Receptor
• Type: Peptides
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/d-trp8-γ-msh.html
• Purity: 99.57
• Solubility: H2O : 12.5 mg/mL (ultrasonic)
• Smiles: OC(C=C1)=CC=C1C[C@H](N)C(N[C@@H](C(C)C)C(N[C@@H](CCSC)C(NCC(N[C@@H](CC2=CN=CN2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O)=O
• Molecular Weight: 1570.77
• References & Citations: [1]Grieco P, et, al. D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity. J Med Chem. 2000 Dec 28; 43(26): 4998-5002.|[2]Kadiri JJ, et, al. Melanocortin 3 receptor activation with [D-Trp8]-γ-MSH suppresses inflammation in apolipoprotein E deficient mice. Eur J Pharmacol. 2020 Aug 5; 880:173186.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
• Clinical Information: No Development Reported