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[D-Trp8]-γ-MSH

CAT: 0804-HY-P1217-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1217-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
[D-Trp8]-γ-MSH is a potent and selective agonist of melanocortin 3 (MC3) receptor, with IC50s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4 and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis[1][2].
CAS Number
321351-81-9
UNSPSC
12352209
Target
Melanocortin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/d-trp8-γ-msh.html
Purity
99.57
Solubility
H2O : 12.5 mg/mL (ultrasonic)
Smiles
OC(C=C1)=CC=C1C[C@H](N)C(N[C@@H](C(C)C)C(N[C@@H](CCSC)C(NCC(N[C@@H](CC2=CN=CN2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C74H99N21O16S
Molecular Weight
1570.77
References & Citations
[1]Grieco P, et, al. D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp (8) on human MC3 receptor selectivity. J Med Chem. 2000 Dec 28; 43 (26) : 4998-5002.|[2]Kadiri JJ, et, al. Melanocortin 3 receptor activation with [D-Trp8]-γ-MSH suppresses inflammation in apolipoprotein E deficient mice. Eur J Pharmacol. 2020 Aug 5; 880:173186.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
MC3R

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