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1,2-DLPC

CAT: 0804-HY-107737-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107737-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
1,2-DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is a ligand for LRH-1 agonists. 1,2-DLPC is a phospholipid used in the synthesis of liposomes. 1,2-DLPC enhances fat breakdown and apoptosis in fat cells through a TNFα-dependent pathway, while also inhibiting palmitate-induced insulin resistance through PPARα-mediated inflammation in muscle cells[1][2][3].
CAS Number
18194-25-7
Product Name Alternative
1,2-Dilauroyl-sn-glycero-3-phosphocholine
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H331, H336, H351, H361, H372, H412
Target
Apoptosis; Liposome; PPAR; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/1-2-dilauroyl-sn-glycero-3-phosphocholine.html
Purity
98.0
Solubility
Ethanol : 100 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCC(OC[C@@H](OC(CCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O
Molecular Formula
C32H64NO8P
Molecular Weight
621.83
Precautions
H302, H315, H319, H331, H336, H351, H361, H372, H412
References & Citations
[1]Matthew E Nipper, et al. Detection of liposome membrane viscosity perturbations with ratiometric molecular rotors. Biochimie. 2011 Jun;93 (6) :988-94.|[2]Jae Man Lee, et al. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature. 2011 May 25;474 (7352) :506-10.|[3]Jinwoo Park, et al. 1,2-Dilinoleoyl-sn-glycero-3-phosphocholine increases insulin sensitivity in palmitate-treated myotubes and induces lipolysis in adipocytes. Biochem Biophys Res Commun. 2020 Nov 26;533 (1) :162-167.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARα

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