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Recombinant Human CCL5

CAT: 0014-50181P-50-1Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0014-50181P-50-1Size:50 µg
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Description
Recombinant human CCL5
CAS Number
9000-83-3
Product Name Alternative
rHuCCL5
Gene Name
CCL5
UniProt
P13501
Cellular Locus
Secreted.
Reactivity
Human
Target Antigen
C-C motif chemokine 5
Target
CCL5
Type
Protein
Applications
Migration assay
Dilution
Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.
Form
Lyophilized
Function
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. RPubMed:1380064, PubMed:15923218, PubMed:16791620, PubMed:17001303, PubMed:23979485, PubMed:8525373, PubMed:9516414}.
Additionnal Information
Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.Migration Assay in L1.2 cells expressing CCR5.
Storage Conditions
12 months from date of receipt, -20°C to -70°C, as supplied. 1 month, 2°C to 8°C, under sterile conditions after reconstitution. 3 months, -20°C to -70°C, under sterile conditions after reconstitution.
Specificity
CCL5
Target Background
CCL5, also known as Regulated on Activation, Normal T-cell Expressed and Secreted (RANTES), is a proinflammatory chemokine that induces migration and activation of leukocytes, and is also implied in HIV infection. CCL5 binds to cell surface receptors CCR1, CCR3, CCR4, and CCR5. Its biological effects on leukocyte activation and HIV infections is dependent upon concentration and on the binding of cell surface glycosaminoglycans.

UniProtKB · P13501

C-C motif chemokine 5

CCL5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P13501
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CCL5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
O43646, Q0QVW8, Q4ZGJ1, Q9NYA2, Q9UBG2, Q9UC99
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

ChemotaxisInflammatory response

Molecular function

Cytokine

PTM

Disulfide bondGlycoproteinOxidation

Cellular component

Secreted

Domain

Signal

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