Recombinant Human CCL3

• Description:

  Recombinant human CCL3

• Product Name Alternative:

  rHuCCL3, MIP-1alpha

• Gene Name:

  CCL3

• UniProt:

  P10147

• Cellular Locus:

  Secreted.

• Reactivity:

  Human

• Target Antigen:

  C-C motif chemokine 3

• Target:

  CCL3

• Type:

  Protein

• Applications:

  Migration assay

• Dilution:

  Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.

• Form:

  Lyophilized

• Function:

  Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. RPubMed:8525373}.

• Additionnal Information:

  Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.Migration of recombinant CCR5- expressing cells.

• Storage Conditions:

  12 months from date of receipt, -20°C to -70°C, as supplied. 1 month,- 20°C to -70°C, under sterile conditions after reconstitution. Best if used immediately after reconstitution. Avoid multiple freeze-thaw cycles.

• Specificity:

  CCL3

• Target Background:

  CCL3, also known as Macrophage Inflammatory Protein-1a (MIP-1a), is a proinflammatory chemokine that stimulates chemotaxis and activation of different cell populations of the immune system. CCL3 binds to CCR1, CCR4, and CCR5 receptors, and it is one of the major HIV- suppressive factors produced by CD8+ T-cells. CCL3 induces dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).

• CAS Number:

  9000-83-3