HMC-B17
CAT:
804-HY-157838
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
HMC-B17
- CAS Number: 2935913-83-8
- UNSPSC Description: HMC-B17 is a selective, orally bioavailable HPK1 inhibitor (IC50 = 1.39 nM) that potentiates anti-PD-L1 efficacy. HMC-B17 potently enhances the IL-2 secretion in Jurkat cells (EC50 = 11.56 nM). HMC-B17 can be used for the research of cancer[1].
- Target Antigen: MAP4K
- Type: Reference compound
- Related Pathways: MAPK/ERK Pathway
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/hmc-b17.html
- Solubility: 10 mM in DMSO
- Smiles: COC1=C(C=C(C=C1)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)C5CCN(C)CC5)OC
- Molecular Weight: 427.54
- References & Citations: [1]Zeng S, et al. Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody. Eur J Med Chem. 2024 Mar 5;267:116206.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported