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HMC-B17

CAT: 0804-HY-157838Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157838Size:1 Each
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Description
HMC-B17 is a selective, orally bioavailable HPK1 inhibitor (IC50 = 1.39 nM) that potentiates anti-PD-L1 efficacy. HMC-B17 potently enhances the IL-2 secretion in Jurkat cells (EC50 = 11.56 nM) . HMC-B17 can be used for the research of cancer[1].
CAS Number
2935913-83-8
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hmc-b17.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C(C=C1)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)C5CCN(C)CC5)OC
Molecular Formula
C27H29N3O2
Molecular Weight
427.54
References & Citations
[1]Zeng S, et al. Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody. Eur J Med Chem. 2024 Mar 5;267:116206.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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