HMC-B17

• Target:

  MAPK

• Related Pathways:

  MAPK

• Bioactivity:

  HMC-B17 is a selective and orally bioavailable HPK1 inhibitor (IC50 = 1.39 nM) that enhances anti-PD-L1 efficacy. It significantly increases IL-2 secretion in Jurkat cells (EC50 = 11.56 nM) and can be utilized for cancer research [1].

• Smiles:

  O(C)C=1C=C(C=2C=3C(NC2)=NC=C(C3)C4=CC=C(C=C4)C5CCN(C)CC5)C=CC1OC

• Molecular Formula:

  C27H29N3O2

• Molecular Weight:

  427.54

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2935913-83-8