Ursodeoxycholic acid

• UNSPSC Description:

  Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active[1][2][3][4].

• Target Antigen:

  Angiotensin-converting Enzyme (ACE); Endogenous Metabolite; FXR; G protein-coupled Bile Acid Receptor 1

• Type:

  Natural Products

• Related Pathways:

  GPCR/G Protein;Metabolic Enzyme/Protease

• Field of Research:

  Cancer; Infection; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/Ursodiol.html

• Smiles:

  C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

• Molecular Weight:

  392.57

• References & Citations:

  [1]Jackson H, et al. Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: a population-based cohort study. Hepatology. 2007 Oct;46(4):1131-7.|[2]Kumar D, et al. Use of ursodeoxycholic acid in liver diseases. J Gastroenterol Hepatol. 2001 Jan;16(1):3-14.|[3]Biao Nie, et al. Specific Bile Acids Inhibit Hepatic Fatty Acid Uptake in Mice. Hepatology. 2012 Oct;56(4):1300-10.|[4]Brevini T, et al. FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2. Nature. 2022 Dec 5.|[5]Winston JA, et al. Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice. PLoS One. 2021;16(2):e0246161. Published 2021 Feb 18. Aquaculture. 2024 Nov 15.|Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9.|Cell Prolif. 2023 Apr 26.|Cells. 2022, 11(19), 2951.|Clin Neuropharmacol. 10.1097.|Free Radic Biol Med. 2020 May 20;152:821-837.|Int J Mol Sci. 2024 Jan 11, 25(2), 919.|Nat Commun. 2023 May 2;14(1):2523.|Nature. 2024 Dec 18.|Neurosci Lett. 2021 Jan 10;741:135493.|Phytomedicine. 2024 Sep:132:155886.|Research Square Preprint. 2021 Aug.|Biochim Biophys Acta Mol Basis Dis. 2024 Mar;1870(3):167029.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  128-13-2