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SCA2 Antibody / ATXN2

CAT: 0800-RQ6945Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6945Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ataxin-2, the protein encoded by the ATXN2 gene, contains a polyglutamine tract, long expansions (greater than 33 repeats) of which result in spinocerebellar ataxia-2 (SCA2), an autosomal dominant form of olivopontocerebellar atrophy. The gene for spinocerebellar ataxia type 2 (SCA2) has been mapped to 12q24.1. Ataxin-2 associates with L- and T-plastin and that overexpression of ataxin-2 leads to accumulation of T-plastin in mammalian cells.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q99700
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human protein (amino acids Q1278-L1313) was used as the immunogen for the SCA2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the SCA2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This SCA2 antibody is available for research use only.
Storage Conditions
After reconstitution, the SCA2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the SCA2 antibody should be determined by the researcher.
Image Legend
IHC staining of FFPE human breast cancer tissue with SCA2 antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

UniProtKB · Q99700

Ataxin-2

ATX2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q99700
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ATXN2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A6NLD4, Q24JQ7, Q6ZQZ7, Q99493
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingTriplet repeat expansion

Disease

Amyotrophic lateral sclerosisNeurodegenerationParkinsonismSpinocerebellar ataxia

Cellular component

Cytoplasm

PTM

Isopeptide bondMethylationPhosphoproteinUbl conjugation

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