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DSP Antibody / Desmoplakin

CAT: 0800-RQ6932Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6932Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Desmoplakin is a protein in humans that is encoded by the DSP gene. This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P15924
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human protein (amino acids N69-H2195) was used as the immunogen for the DSP antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the DSP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This DSP antibody is available for research use only.
Storage Conditions
After reconstitution, the DSP antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the DSP antibody should be determined by the researcher.
Image Legend
Flow cytometry testing of human PC-3 cells with DSP antibody at 1ug/million cells (blocked with goat sera) ; Red=cells alone, Green=isotype control, Blue= DSP antibody.

UniProtKB · P15924

Desmoplakin

DESP_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P15924
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DSP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
DP
EC number
—
Processing
—
Secondary accessions
B2RTT2, D7RX09, O75993, Q14189, Q9UHN4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

CardiomyopathyDisease variantEpidermolysis bullosaHypotrichosisPalmoplantar keratoderma

Cellular component

Cell junctionCell membraneCell projectionCytoplasmMembraneNucleus

Domain

Coiled coilRepeatSH3 domain

Molecular function

DNA-binding

PTM

MethylationPhosphoprotein
Product Datasheet
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