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Desmoplakin Antibody / DSP

CAT: 0800-RQ4353Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4353Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Desmoplakin is a protein in humans that is encoded by the DSP gene. This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P15924
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant human protein corresponding to amino acids Q1810-A2092 was used as the immunogen for the Desmoplakin antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the Desmoplakin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Desmoplakin antibody is available for research use only.
Storage Conditions
After reconstitution, the Desmoplakin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Desmoplakin antibody should be determined by the researcher.
Image Legend
Western blot testing of human HepG2 cell lysate with Desmoplakin antibody at 0.5ug/ml. Predicted molecular weight: ~332 kDa (isoform DPI), ~260 kDa (isoform DPII), ~279 kDa (isoform DPIa) .

UniProtKB · P15924

Desmoplakin

DESP_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P15924
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DSP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
DP
EC number
—
Processing
—
Secondary accessions
B2RTT2, D7RX09, O75993, Q14189, Q9UHN4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

CardiomyopathyDisease variantEpidermolysis bullosaHypotrichosisPalmoplantar keratoderma

Cellular component

Cell junctionCell membraneCell projectionCytoplasmMembraneNucleus

Domain

Coiled coilRepeatSH3 domain

Molecular function

DNA-binding

PTM

MethylationPhosphoprotein

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