KGP-25

• Description :

  KGP-25 is an inhibitor of voltage-gated sodium channel 1.8 (Nav1.8), which can be used for analgesia by targeting Nav1.8 in the peripheral nervous system (PNS) . KGP-25 can also target γ-aminobutyric acid subtype A receptor (GABAA) in the central nervous system (CNS) for general anesthesia[1].

• UNSPSC :

  12352005

• Target :

  GABA Receptor; Sodium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/kgp-25.html

• Purity :

  95.0

• Smiles :

  CC(C1=C(C(C(C)C)=CC=C1)OC(OCC[NH+](CC)CC)=O)C.[Cl-]

• Molecular Formula :

  C19H32ClNO3

• Molecular Weight :

  357.92

• References & Citations :

  [1]Huang T, ey al. Molecular Transformers: Adaptive Multitarget Ligands for Esterase-Induced Transition from Analgesics to Anesthetics. J Med Chem. 2024 Jul 25;67 (14) :12349-12365.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported