3,4-Dimethoxychalcone

• Description:

  3,4-Dimethoxychalcone is a Caloric restriction mimetics (CRMs) . 3,4-Dimethoxychalcone induces the deacetylation of cytoplasmic proteins and stimulates autophagy flux. 3,4-Dimethoxychalcone can be used for cardiac and cancer diseases research[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Autophagy; Bacterial

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Autophagy

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/3-4-dimethoxychalcone.html

• Concentration:

  10mM

• Purity:

  99.94

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (C1=CC=CC=C1) /C=C/C2=CC=C (OC) C (OC) =C2

• Molecular Formula:

  C17H16O3

• Molecular Weight:

  268.31

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Okolo EN, et al. New chalcone derivatives as potential antimicrobial and antioxidant agent. Sci Rep. 2021 Nov 5;11 (1) :21781.|[2]Chen G, et al. 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB. EMBO Mol Med. 2019 Nov 7;11 (11) :e10469.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  5416-71-7