3,4-Dimethoxychalcone

• Description :

  3,4-Dimethoxychalcone is a Caloric restriction mimetics (CRMs) . 3,4-Dimethoxychalcone induces the deacetylation of cytoplasmic proteins and stimulates autophagy flux. 3,4-Dimethoxychalcone can be used for cardiac and cancer diseases research[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Autophagy; Bacterial

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Autophagy

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/3-4-dimethoxychalcone.html

• Concentration :

  10mM

• Purity :

  99.94

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=CC=CC=C1)/C=C/C2=CC=C(OC)C(OC)=C2

• Molecular Formula :

  C17H16O3

• Molecular Weight :

  268.31

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Okolo EN, et al. New chalcone derivatives as potential antimicrobial and antioxidant agent. Sci Rep. 2021 Nov 5;11 (1) :21781.|[2]Chen G, et al. 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB. EMBO Mol Med. 2019 Nov 7;11 (11) :e10469.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [5416-71-7]