Tomatine

• Description :

  Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.) . Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity[1].

• CAS Number :

  [17406-45-0]

• Product Name Alternative :

  α-Tomatine; Lycopersicin; Tomatin

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Apoptosis; Proteasome

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/tomatine.html

• Purity :

  99.90

• Solubility :

  DMSO : 43.75 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@@]34CC[C@H](C)CN4)([H])C[C@@]1([H])[C@@](CC[C@]5([H])[C@@]6(CC[C@H](O[C@]([C@@H]([C@@H](O)[C@H]7O[C@@](O[C@H](CO)[C@@H](O)[C@@H]8O[C@@](OC[C@@H](O)[C@@H]9O)([H])[C@@H]9O)([H])[C@@H]8O[C@]([C@@H]([C@@H](O)[C@@H]%10O)O)([H])O[C@@H]%10CO)O)([H])O[C@@H]7CO)C5)C)([H])[C@]6([H])CC2

• Molecular Formula :

  C50H83NO21

• Molecular Weight :

  1034.19

• Precautions :

  H302

• References & Citations :

  [1]da Silva DC, et al. Neurotoxicity of the steroidal alkaloids tomatine and tomatidine is RIP1 kinase- and caspase-independent and involves the eIF2α branch of the endoplasmic reticulum. J Steroid Biochem Mol Biol. 2017 Jul;171:178-186.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported