Tomatidine (hydrochloride)

• UNSPSC Description:

  Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling[1]. Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans[2].

• Target Antigen:

  Autophagy; Endogenous Metabolite; JNK; NF-κB

• Type:

  Natural Products

• Related Pathways:

  Autophagy;MAPK/ERK Pathway;Metabolic Enzyme/Protease;NF-κB

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Tomatidine_hydrochloride.html

• Purity:

  99.58

• Solubility:

  DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C)|Ethanol : 3.45 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)|Methanol : 12.5 mg/mL (ultrasonic)

• Smiles:

  [H][C@]1(O[C@]2(NC[C@@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC[C@@]6([H])C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H].Cl[H]

• Molecular Weight:

  452.11

• References & Citations:

  [1]Chiu FL, et al. Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages. FEBS Lett. 2008 Jul 9;582(16):2407-12.|[2]Anil Ahsan, et al. Tomatidine Protects Against Ischemic Neuronal Injury by Improving Lysosomal Function. Eur J Pharmacol. 2020 Jun 21;173280.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  No Development Reported

• CAS Number:

  6192-62-7