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B-AP15 (NSC-687852)

CAT: 0421-27701-1Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0421-27701-1Size:5 mg
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Description
Blocks 26S proteasome activity by inhibiting the ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) activities of the 19S regulatory subunit without affecting the catalytic activity of the 20S core subunit. b-AP15 displays several differences to bortezomib including insensitivity to over-expression of the anti-apoptotic mediator Bcl-2 and anti-tumor activity in four solid tumor models.
CAS Number
1009817-63-3
Applications
Suitable for validation studies of the deubiquitinating activities of the 19S regulatory particle as a drug target, as well as cell-based and in vitro characterization UCH-L5 or USP14 activity.
Purity
≥ 98% by HPLC.
Format
Pale yellow powder
Solubility
Soluble in DMSO (35 mg/mL)
Molecular Formula
C22H17N3O6
Shipping Conditions
Gel Packs
Calculated Molecular Weight
419.4 Da

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