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CD226:CD112 Homogeneous Assay Kit

CAT: 0421-72051Size: 384 ReactionsDry Ice: YesHazardous: No
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CAT#:0421-72051Size:384 Reactions
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD226 is an activating receptor expressed on the surface of natural killer (NK) cells, monocytes, platelets, and T cells. Its natural ligands are CD112 and CD155 which are expressed by antigen presenting cells (APC) . Binding of CD226 to either CD112 or CD155 triggers NK cell effector function and can promote Th1 cell differentiation in T cells. CD226 competes for binding with CD112 and CD155 with the co-inhibitory receptor TIGIT. Agonistic CD226 monoclonal antibodies are being explored as potential therapeutics in settings where immune activation is beneficial, such as cancer.
Description
The CD226:CD112 Homogeneous Assay Kit is designed to measure the inhibition of CD226 binding to CD112 (PVRL2) . The CD226:CD112 Homogeneous Assay Kit comes in a convenient AlphaLISA® format with purified biotinylated CD226, His-tagged CD112, and assay buffer to perform a total of 384 reactions. With this kit, only three simple steps on a microtiter plate are required. First, a sample containing CD226 and an inhibitor of choice is incubated with the CD112 for 60 minutes. Next, acceptor beads are added, then donor beads, followed by reading the Alpha-counts.Need us to run inhibitor screens or profile your compounds against CD226:CD112? Check out ourImmunotherapy Biochemical Screening Services.
UniProt
CD226: Q15762; CD112: Q92692
Applications
Useful for screening for inhibitors of CD226 binding to CD112
Format
CatalogNumberComponentAmountStorage71253CD226-Fc-biotin2 x 8 µg-80°CAvoid freeze/thaw cycles!71197CD112-His2 x 8 µg-80°C793113x Immuno Buffer 14 ml-20°C
Shipping Conditions
Dry Ice
Storage Conditions
Stable for at least 6 months from date of receipt when stored as directed.
Notes
AlphaScreen®and AlphaLISA®are registered trademarks of PerkinElmer, Inc.

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