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BACE1 Assay Kit

CAT: 0421-71656Size: 96 ReactionsDry Ice: YesHazardous: No
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CAT#:0421-71656Size:96 Reactions
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Bace1 (β-secretase 1, also known as beta-site amyloid precursor protein cleaving enzyme 1 and ASP2, GenBank Accession No. NM_012104.4) is an aspartic protease involved in the processing of the Amyloid precursor protein (APP) . Cleavage of APP by BACE1 followed by γ-secretase results in β-amyloid peptide production, which ultimately leads to toxic Amyloid β accumulation. Amyloid β aggregation may play a critical role in Alzheimer’s disease pathogenesis, suggesting that BACE1 could be a potential therapeutic target in this disease.
Description
The BACE1 Assay Kit is designed to measure BACE1 activity for screening and profiling applications using a labeled peptide substrate in a homogeneous fluorogenic assay.The peptide substrate contains a fluorescence Donor that is quenched by an  Acceptor when the peptide is intact. Upon BACE1-mediated cleavage the two peptide fragments pull apart, releasing the highly fluorescent peptide fragment from quenching. Therefore, the fluorescence intensity increases proportionally to the activity of BACE1.Need us to run inhibitor screens or profile your compounds against BACE1? Check out ourProtease Screening Services.This product has beencited 1 time.
UniProt
P56817
Applications
1. Study enzyme kinetics2. Screen for small molecular inhibitors for drug discovery and High Throughput (HTS) applications.
Format
CatalogNumberReagentAmountStorage71657BACE120 µg-80°CBACE1 assay buffer12 ml4°CBACE1 peptide substrate100 µl-80°C7968596-well plate, black1RT
Shipping Conditions
Dry Ice
Storage Conditions
At least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.

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Alternative Products

CatalogName
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