PCGF6, GST-tag Recombinant

• Background:

  Transcriptional repressor that modulates the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

• Description:

  Human Polycomb group RING finger protein 6 (PCGF6), GenBank Accession No. NM_001011663, a.a. 2-350 (end), with N-terminal GST-tag, MW=65.7 kDa, expressed in a baculovirus expression system.

• UniProt:

  Q9BYE7

• Tag:

  N-terminal GST-tag

• Applications:

  Useful for protein binding assays, screening inhibitors, and selectivity profiling.

• Purity:

  ≥ 86%

• Format:

  Aqueous buffer solution

• Shipping Conditions:

  -80°C

• Storage Conditions:

  ≥ 6 months at -80°C

• Calculated Molecular Weight:

  65.7 kDa

• Formulation:

  40 mM Tris. pH 8.0,110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, and 20% glycerol.