SIRT6-IN-2

SIRT6-IN-2

• CAS Number: 891002-11-2
• UNSPSC Description: SIRT6-IN-2 (Compound 5) is a selective SIRT6 inhibitor (IC50: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects[1].
• Target Antigen: Sirtuin
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/sirt6-in-2.html
• Purity: 99.85
• Solubility: DMSO : 62.5 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC=C(NC(C2=CC=CO2)=O)C=C1)NC3=CC(C(O)=O)=C(O)C=C3
• Molecular Weight: 366.32
• References & Citations: [1]Damonte P, et al. SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects. Bioorg Med Chem. 2017 Oct 15;25(20):5849-5858.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported