L-AP4 (monohydrate)

• Description :

  L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2].

• Product Name Alternative :

  L-APB (monohydrate)

• UNSPSC :

  12352211

• Target :

  MGluR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/l-ap4-monohydrate.html

• Purity :

  99.0

• Solubility :

  DMSO : 10 mg/mL (ultrasonic)

• Smiles :

  O=C(O)[C@@H](N)CCP(O)(O)=O.O

• Molecular Formula :

  C4H12NO6P

• Molecular Weight :

  201.11

• References & Citations :

  [1]Selvam C, et al. Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem. 2018 Mar 8;61 (5) :1969-1989.|[2]Chen SR, et al. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. J Pharmacol Exp Ther. 2005 Jan;312 (1) :120-6.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MGluR4; mGluR6; mGluR7; mGluR8

• CAS Number :

  [2247534-79-6]