L-AP4

CAT: 0804-HY-100781A-01Size: 1 mgDry Ice: NoHazardous: No

CAT#:0804-HY-100781A-01Size:1 mg

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Description

L-AP4 (L-APB) is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2].

CAS Number

[23052-81-5]

Product Name Alternative

L-APB

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/L-APB.html

Purity

99.01

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(O)[C@@H](N)CCP(O)(O)=O

Molecular Formula

C4H10NO5P

Molecular Weight

183.10

Precautions

H302, H312, H332

References & Citations

[1]Selvam C, et al. Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem. 2018 Mar 8;61 (5) :1969-1989.|[2]Chen SR, et al. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. J Pharmacol Exp Ther. 2005 Jan;312 (1) :120-6.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MGluR4; mGluR6; mGluR7; mGluR8

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