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DL-AP4

CAT: 804-HY-100743-01Size: 25 mgDry Ice: NoHazardous: No
25 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system[1][2][3].
CAS Number
[6323-99-5]
Product Name Alternative
2-Amino-4-phosphonobutyric acid
UNSPSC
12352211
Hazard Statement
H302, H312, H332
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dl-ap4.html
Purity
98.0
Solubility
H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)C(N)CCP(O)(O)=O
Molecular Formula
C4H10NO5P
Molecular Weight
183.10
Precautions
H302, H312, H332
References & Citations
[1]Cull-Candy SG, et al. 2-Amino-4-phosphonobutyric acid as a glutamate antagonist on locust muscle. Nature. 1976 Jul 29;262 (5567) :408-9.|[2]Crooks SL, et al. Cyclic analogues of 2-amino-4-phosphonobutanoic acid (APB) and their inhibition of hippocampal excitatory transmission and displacement of [3H]APB binding. J Med Chem. 1986 Oct;29 (10) :1988-95.|[3]Yamashita M, et al. Responses of rod bipolar cells isolated from the rat retina to the glutamate agonist 2-amino-4-phosphonobutyric acid (APB) . J Neurosci. 1991 Aug;11 (8) :2372-82.|[4]Ellis EM, et al. Separate ON and OFF pathways in vertebrate vision first arose during the Cambrian. Curr Biol. 2020 Jun 8;30 (11) :R633-R634.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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