SDX-7539

• Description:

  SDX-7539 is a selective inhibitor for Methionine aminopeptidase type 2 (MetAP2) . SDX-7539 inhibits proliferarion of HUVECs with an IC50 of 120 μM. SDX-7539 exhibits antitumor activity in NSCLC xenograft athymic nude mice[1].

• UNSPSC:

  12352005

• Target:

  MetAP

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sdx-7539.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][C@@]1 ([C@@H] ([C@@H] (CC[C@@]12OC2) OC (N[C@@H]3CC[C@@H] (N) CC3) =O) OC) [C@]4 (O[C@@H]4C/C=C (C) \C) C

• Molecular Formula:

  C23H38N2O5

• Molecular Weight:

  422.56

• References & Citations:

  [1]Cornelius P., et al., Pharmacological Characterization of SDX-7320/Evexomostat: a Novel Methionine Aminopeptidase Type 2 Inhibitor with Anti-Tumor and Anti-Metastatic Activity, 2024

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1631953-52-0