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MSH2 Antibody

CAT: 0800-V9294-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#: V9294-100UGSize: 100 µg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) . Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
IDP43246
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human MSH2 protein was used as the immunogen for the MSH2 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
MSH2/6852
Applications
WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the MSH2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MSH2 antibody is available for research use only.
Storage Conditions
Aliquot the MSH2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the MSH2 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
IHC staining of FFPE human colon tissue with MSH2 antibody (clone MSH2/6852) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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