Products for Research Use Only
RegisterLogin

MSH6 Antibody

CAT: 0800-V4884SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-V4884SAF-100UGSize:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P52701
Host
Mouse
Reactivity
Human
Immunogen
A recombinant fragment of human MSH6 protein (within amino acids 300-600) was used as the immunogen for the MSH6 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
MSH6/6805
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the MSH6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MSH6 antibody is available for research use only.
Storage Conditions
Aliquot the MSH6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the MSH6 antibody should be determined by the researcher.
Location
Nucleus

UniProtKB · P52701

DNA mismatch repair protein Msh6

MSH6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P52701
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MSH6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hMSH6
EC number
—
Processing
—
Secondary accessions
B4DF41, B4E3I4, F5H2F9, O43706, O43917, Q8TCX4, Q9BTB5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

ChromosomeNucleus

Disease

Disease variantHereditary nonpolyposis colorectal cancer

Biological process

DNA damageDNA repairHost-virus interaction

Molecular function

DNA-binding

Related Products

CatalogName
V5723-20UGRecombinant GTBP Antibody / G/T mismatch-binding protein / MSH6
V5723SAF-100UGRecombinant GTBP Antibody / G/T mismatch-binding protein / MSH6
V5723-100UGRecombinant GTBP Antibody / G/T mismatch-binding protein / MSH6
F52414-0.4MLMSH2 Antibody
R34074-100UGMSH5 Antibody
V7964SAF-100UGMSH2 Antibody
V9294SAF-100UGMSH2 Antibody
V7964-20UGMSH2 Antibody
V9303SAF-100UGMSH2 Antibody
F41546-0.4MLMSH2 Antibody

Alternative Products

CatalogName
70R-12156MSH6 antibody

Popular Products