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COX2 Antibody / PTGS2

CAT: 0800-V8996SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8996SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (COX2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA) . Cox-1 and COX2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS) . Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. COX2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P35354
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 442-572 was used as the immunogen for the COX2 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
COX2/2377
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the COX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This COX2 antibody is available for research use only.
Storage Conditions
Aliquot the COX2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the COX2 antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
IHC staining of FFPE human prostate cancer with COX2 antibody (clone COX2/2377) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P35354

Prostaglandin G/H synthase 2

PGH2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35354
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTGS2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.14.99.1
Processing
Precursor
Secondary accessions
A8K802, Q16876
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationDisulfide bondGlycoproteinS-nitrosylation

Molecular function

DioxygenaseOxidoreductasePeroxidase

Cellular component

Endoplasmic reticulumMembraneMicrosomeNucleus

Biological process

Fatty acid biosynthesisFatty acid metabolismLipid biosynthesisLipid metabolismProstaglandin biosynthesisProstaglandin metabolism

Ligand

HemeIronMetal-binding

Domain

Signal
Product Datasheet
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