CD74 Antibody

• Description:

  CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+) .

• Specifications:

  ELISA (order BSA-free format for coating)

• UniProt:

  P044233

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  SU-DHL-4 lymphoma cells were used as the immunogen for the CD74 antibody.

• Clonality:

  Recombinant Monoclonal

• Isotype:

  IgG κ

• Clone:

  CLIP/7023R

• Type:

  Recombinant

• Applications:

  ELISA

• Purity:

  Protein A/G affinity

• Format:

  Purified

• Buffer:

  1 mg/ml in 1X PBS; BSA free, sodium azide free

• Reconstitution:

  Aliquot the CD74 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This CD74 antibody is available for research use only.

• Storage Conditions:

  Aliquot the CD74 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  1 mg/mL in 1X PBS; BSA free, sodium azide free

• Applications Notes:

  Optimal dilution of the CD74 antibody should be determined by the researcher.

• CAS Number:

  9000-83-3

• Location:

  Cell surface, Paranuclear globular

• Image Legend:

  SDS-PAGE analysis of purified, BSA-free CD74 antibody (clone CLIP/7023R) as confirmation of integrity and purity.